Drug interactions
Apalutamide + Danazol
Severity: Minor
Apalutamide and Danazol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and might slightly increase apalutamide exposure. Apalutamide is also metabolised by CYP2C8, and the overall clinical effect is expected to be small.
What this interaction means in plain words
Apalutamide and Danazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by danazol may modestly reduce apalutamide clearance.
What to do
No routine dose change is needed; monitor for apalutamide adverse effects such as rash, fatigue and hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Danazol?
MediHelp rates the interaction as minor. Apalutamide and Danazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and might slightly increase apalutamide exposure. Apalutamide is also metabolised by CYP2C8, and the overall clinical effect is expected to be small.
How serious is the interaction between Apalutamide and Danazol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for apalutamide adverse effects such as rash, fatigue and hypertension.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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