Drug interactions
Apalutamide + Darifenacin
Severity: Moderate
Apalutamide and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can substantially lower darifenacin concentrations. This may cause loss of control of overactive bladder symptoms.
What this interaction means in plain words
Apalutamide and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Darifenacin belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by apalutamide increases darifenacin metabolism.
What to do
Monitor for loss of symptom control and titrate darifenacin within its labeled range or switch to an agent less dependent on CYP3A4 if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Darifenacin?
MediHelp rates the interaction as moderate. Apalutamide and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can substantially lower darifenacin concentrations. This may cause loss of control of overactive bladder symptoms.
How serious is the interaction between Apalutamide and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and titrate darifenacin within its labeled range or switch to an agent less dependent on CYP3A4 if the response is inadequate.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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