Drug interactions
Apalutamide + Doxorubicin
Severity: Minor
Apalutamide and Doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower doxorubicin concentrations, but CYP3A4 is only a minor contributor to doxorubicin clearance, so the effect is likely small.
What this interaction means in plain words
Apalutamide and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Doxorubicin belongs to Oncology.
Why it happens
Possible modest induction of CYP3A4 and transporters increases doxorubicin elimination.
What to do
No dose adjustment needed; monitor for therapeutic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Doxorubicin
Frequently asked questions
Can I take Apalutamide with Doxorubicin?
MediHelp rates the interaction as minor. Apalutamide and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide may lower doxorubicin concentrations, but CYP3A4 is only a minor contributor to doxorubicin clearance, so the effect is likely small.
How serious is the interaction between Apalutamide and Doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; monitor for therapeutic response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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