Drug interactions
Apalutamide + Enalapril
Severity: Minor
Apalutamide and Enalapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an enzyme and transporter inducer that may lower exposure of some OATP1B1 substrates. Enalapril is a prodrug whose activation depends on hepatic esterases, and any resulting change in effect is likely small and poorly characterized.
What this interaction means in plain words
Apalutamide and Enalapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Enalapril belongs to Cardiovascular.
Why it happens
Possible weak induction of OATP1B1-mediated uptake by apalutamide, which could modestly lower enalapril exposure; clinical significance is uncertain.
What to do
No dose change is usually needed. Monitor blood pressure after starting or stopping apalutamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Enalapril?
MediHelp rates the interaction as minor. Apalutamide and Enalapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is an enzyme and transporter inducer that may lower exposure of some OATP1B1 substrates. Enalapril is a prodrug whose activation depends on hepatic esterases, and any resulting change in effect is likely small and poorly characterized.
How serious is the interaction between Apalutamide and Enalapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor blood pressure after starting or stopping apalutamide.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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