Drug interactions
Apalutamide + Ergoloid mesylates
Severity: Moderate
Apalutamide and Ergoloid mesylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower ergoloid concentrations and reduce its therapeutic effect. The clinical consequence is likely modest compared with ergot alkaloids.
What this interaction means in plain words
Apalutamide and Ergoloid mesylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4, increasing ergoloid metabolism.
What to do
Monitor for loss of cognitive or symptomatic benefit and adjust the ergoloid dose if needed. Consider whether ergoloid therapy is still warranted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ergoloid mesylates?
MediHelp rates the interaction as moderate. Apalutamide and Ergoloid mesylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may lower ergoloid concentrations and reduce its therapeutic effect. The clinical consequence is likely modest compared with ergot alkaloids.
How serious is the interaction between Apalutamide and Ergoloid mesylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of cognitive or symptomatic benefit and adjust the ergoloid dose if needed. Consider whether ergoloid therapy is still warranted.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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