Drug interactions
Apalutamide + Escitalopram
Severity: Moderate
Apalutamide and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C19 and CYP3A4, which contribute to escitalopram metabolism. Escitalopram exposure may fall, leading to reduced antidepressant effect and possible relapse.
What this interaction means in plain words
Apalutamide and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Escitalopram belongs to Central Nervous System.
Why it happens
Induction of CYP2C19 and CYP3A4 by apalutamide increases escitalopram clearance.
What to do
Monitor for loss of antidepressant or anxiolytic effect and increase the escitalopram dose if needed within labeled limits. Reassess the dose when apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Escitalopram?
MediHelp rates the interaction as moderate. Apalutamide and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP2C19 and CYP3A4, which contribute to escitalopram metabolism. Escitalopram exposure may fall, leading to reduced antidepressant effect and possible relapse.
How serious is the interaction between Apalutamide and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant or anxiolytic effect and increase the escitalopram dose if needed within labeled limits. Reassess the dose when apalutamide is stopped.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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