Drug interactions
Apalutamide + Estradiol vaginal
Severity: Minor
Apalutamide and Estradiol vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estradiol is metabolized by CYP3A4, which apalutamide induces. Low-dose vaginal estradiol has mainly local effects, so the effect on systemic exposure would be small and unlikely to matter for most patients.
What this interaction means in plain words
Apalutamide and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Apalutamide induces CYP3A4, increasing estradiol metabolism.
What to do
No adjustment is typically needed. Reassess symptom relief if the local response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Estradiol vaginal?
MediHelp rates the interaction as minor. Apalutamide and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estradiol is metabolized by CYP3A4, which apalutamide induces. Low-dose vaginal estradiol has mainly local effects, so the effect on systemic exposure would be small and unlikely to matter for most patients.
How serious is the interaction between Apalutamide and Estradiol vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is typically needed. Reassess symptom relief if the local response is poor.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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