Drug interactions
Apalutamide + Estrogens conjugated synthetic
Severity: Moderate
Apalutamide and Estrogens conjugated synthetic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce estrogen exposure, leading to recurrence of menopausal symptoms or inadequate endometrial or bone protection.
What this interaction means in plain words
Apalutamide and Estrogens conjugated synthetic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4 and conjugating enzymes, increasing estrogen clearance.
What to do
Monitor symptom control and adjust the estrogen dose as needed. Consider that apalutamide is used in men, so confirm the indication for this combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Estrogens conjugated synthetic?
MediHelp rates the interaction as moderate. Apalutamide and Estrogens conjugated synthetic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce estrogen exposure, leading to recurrence of menopausal symptoms or inadequate endometrial or bone protection.
How serious is the interaction between Apalutamide and Estrogens conjugated synthetic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and adjust the estrogen dose as needed. Consider that apalutamide is used in men, so confirm the indication for this combination.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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