Drug interactions
Apalutamide + Ethosuximide
Severity: Moderate
Apalutamide and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can reduce ethosuximide concentrations, since ethosuximide is partly metabolized by CYP3A4. Loss of seizure control (absence seizures) may result.
What this interaction means in plain words
Apalutamide and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Ethosuximide belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by apalutamide increases ethosuximide metabolism.
What to do
Monitor seizure frequency and ethosuximide serum levels, and increase the ethosuximide dose if needed. Re-check levels and reduce the dose if apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ethosuximide?
MediHelp rates the interaction as moderate. Apalutamide and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can reduce ethosuximide concentrations, since ethosuximide is partly metabolized by CYP3A4. Loss of seizure control (absence seizures) may result.
How serious is the interaction between Apalutamide and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and ethosuximide serum levels, and increase the ethosuximide dose if needed. Re-check levels and reduce the dose if apalutamide is stopped.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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