Drug interactions
Apalutamide + Fentanyl intranasal
Severity: Moderate
Apalutamide and Fentanyl intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce fentanyl concentrations and cause inadequate analgesia. Stopping apalutamide later could allow fentanyl levels to rise.
What this interaction means in plain words
Apalutamide and Fentanyl intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4, the main pathway of fentanyl clearance.
What to do
Monitor pain control and titrate the fentanyl dose upward if needed. Reassess for opioid toxicity when apalutamide is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Fentanyl intranasal?
MediHelp rates the interaction as moderate. Apalutamide and Fentanyl intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce fentanyl concentrations and cause inadequate analgesia. Stopping apalutamide later could allow fentanyl levels to rise.
How serious is the interaction between Apalutamide and Fentanyl intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate the fentanyl dose upward if needed. Reassess for opioid toxicity when apalutamide is discontinued.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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