Drug interactions
Apalutamide + Fexinidazole
Severity: Major
Apalutamide and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may alter exposure to fexinidazole's active metabolites, and the legacy direction of effect is uncertain. Fexinidazole carries QT prolongation risk, and increased metabolite exposure could heighten it.
What this interaction means in plain words
Apalutamide and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Apalutamide induces CYP enzymes involved in fexinidazole metabolism, while fexinidazole may inhibit CYP3A4; net effect is not well characterized.
What to do
Avoid combination and choose alternatives where possible. If used, obtain an ECG and monitor electrolytes and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Fexinidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Fexinidazole?
MediHelp rates the interaction as major. Apalutamide and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may alter exposure to fexinidazole's active metabolites, and the legacy direction of effect is uncertain. Fexinidazole carries QT prolongation risk, and increased metabolite exposure could heighten it.
How serious is the interaction between Apalutamide and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination and choose alternatives where possible. If used, obtain an ECG and monitor electrolytes and QTc.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
