Drug interactions
Apalutamide + Flurazepam
Severity: Moderate
Apalutamide and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce plasma levels of flurazepam and its active metabolites, weakening the hypnotic effect. Insomnia or reduced sedation may result.
What this interaction means in plain words
Apalutamide and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4, which contributes to the metabolism of flurazepam.
What to do
Monitor for reduced hypnotic effect and adjust the dose cautiously, or choose a benzodiazepine or hypnotic not dependent on CYP3A4, such as temazepam or lorazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Flurazepam?
MediHelp rates the interaction as moderate. Apalutamide and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce plasma levels of flurazepam and its active metabolites, weakening the hypnotic effect. Insomnia or reduced sedation may result.
How serious is the interaction between Apalutamide and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic effect and adjust the dose cautiously, or choose a benzodiazepine or hypnotic not dependent on CYP3A4, such as temazepam or lorazepam.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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