Drug interactions
Apalutamide + Fluticasone furoate
Severity: Moderate
Apalutamide and Fluticasone furoate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP3A4 and can lower fluticasone furoate exposure. Reduced corticosteroid effect may lead to poorer control of asthma or rhinitis. The clinical impact is likely modest because of the low-dose topical use.
What this interaction means in plain words
Apalutamide and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4, increasing fluticasone furoate clearance.
What to do
Monitor for loss of symptom control and increase therapy or choose an alternative if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Fluticasone furoate?
MediHelp rates the interaction as moderate. Apalutamide and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP3A4 and can lower fluticasone furoate exposure. Reduced corticosteroid effect may lead to poorer control of asthma or rhinitis. The clinical impact is likely modest because of the low-dose topical use.
How serious is the interaction between Apalutamide and Fluticasone furoate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and increase therapy or choose an alternative if control worsens.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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