Drug interactions
Apalutamide + Fluticasone inhaled
Severity: Minor
Apalutamide and Fluticasone inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 induction by apalutamide may lower systemic exposure to inhaled fluticasone. Because inhaled fluticasone acts mainly locally and has low systemic bioavailability, the clinical impact is likely small.
What this interaction means in plain words
Apalutamide and Fluticasone inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Apalutamide induces CYP3A4, increasing metabolism of the swallowed and absorbed fraction of fluticasone.
What to do
No dose change is usually needed; monitor asthma or COPD control and review therapy if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Fluticasone inhaled?
MediHelp rates the interaction as minor. Apalutamide and Fluticasone inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Strong CYP3A4 induction by apalutamide may lower systemic exposure to inhaled fluticasone. Because inhaled fluticasone acts mainly locally and has low systemic bioavailability, the clinical impact is likely small.
How serious is the interaction between Apalutamide and Fluticasone inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor asthma or COPD control and review therapy if symptoms worsen.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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