Drug interactions
Apalutamide + Glimepiride-pioglitazone
Severity: Moderate
Apalutamide and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C9 and CYP3A4, which can lower glimepiride and pioglitazone exposure. Glycemic control may worsen.
What this interaction means in plain words
Apalutamide and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Induction of CYP2C9 and CYP3A4 by apalutamide increases metabolism of glimepiride and pioglitazone.
What to do
Monitor blood glucose and increase antidiabetic doses as needed; reassess after apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Apalutamide and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP2C9 and CYP3A4, which can lower glimepiride and pioglitazone exposure. Glycemic control may worsen.
How serious is the interaction between Apalutamide and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and increase antidiabetic doses as needed; reassess after apalutamide is stopped.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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