Drug interactions
Apalutamide + Isoniazid
Severity: Minor
Apalutamide and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may modestly increase apalutamide exposure through CYP3A4 inhibition. Apalutamide labeling indicates that even strong CYP3A4 inhibitors do not require a starting dose change, so a weak inhibitor is of limited concern.
What this interaction means in plain words
Apalutamide and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid slightly reducing apalutamide metabolism.
What to do
No initial dose adjustment is needed. Monitor tolerability, for example rash, fatigue and falls, and reduce the dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Isoniazid?
MediHelp rates the interaction as minor. Apalutamide and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may modestly increase apalutamide exposure through CYP3A4 inhibition. Apalutamide labeling indicates that even strong CYP3A4 inhibitors do not require a starting dose change, so a weak inhibitor is of limited concern.
How serious is the interaction between Apalutamide and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No initial dose adjustment is needed. Monitor tolerability, for example rash, fatigue and falls, and reduce the dose if adverse effects occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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