Drug interactions
Apalutamide + Ixabepilone
Severity: Major
Apalutamide and Ixabepilone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and may speed up the metabolism of ixabepilone, a CYP3A4 substrate. Lower ixabepilone exposure could reduce antitumor efficacy.
What this interaction means in plain words
Apalutamide and Ixabepilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 by apalutamide increases the clearance of ixabepilone.
What to do
Avoid the combination where possible and choose an agent that does not induce CYP3A4. If it cannot be avoided, watch closely for loss of response and follow labeling for ixabepilone dosing with strong inducers.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ixabepilone?
MediHelp rates the interaction as major. Apalutamide and Ixabepilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and may speed up the metabolism of ixabepilone, a CYP3A4 substrate. Lower ixabepilone exposure could reduce antitumor efficacy.
How serious is the interaction between Apalutamide and Ixabepilone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an agent that does not induce CYP3A4. If it cannot be avoided, watch closely for loss of response and follow labeling for ixabepilone dosing with strong inducers.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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