Drug interactions
Apalutamide + Ketamine
Severity: Moderate
Apalutamide and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can lower exposure to ketamine, which is metabolized in part by CYP3A4. This may reduce anesthetic or analgesic effect, particularly with oral dosing.
What this interaction means in plain words
Apalutamide and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Ketamine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 (and CYP2B6) increases ketamine metabolism.
What to do
Titrate ketamine to clinical response and expect higher dose requirements. Monitor for inadequate analgesia or sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ketamine?
MediHelp rates the interaction as moderate. Apalutamide and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can lower exposure to ketamine, which is metabolized in part by CYP3A4. This may reduce anesthetic or analgesic effect, particularly with oral dosing.
How serious is the interaction between Apalutamide and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to clinical response and expect higher dose requirements. Monitor for inadequate analgesia or sedation.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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