Drug interactions
Apalutamide + Lansoprazole
Severity: Moderate
Apalutamide and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C19 and CYP3A4, the main routes of lansoprazole clearance, which may lower lansoprazole exposure. Acid suppression may be weaker.
What this interaction means in plain words
Apalutamide and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Apalutamide induces CYP2C19 and CYP3A4, increasing lansoprazole metabolism.
What to do
Monitor for loss of acid control and increase the lansoprazole dose if needed. Consider an alternative acid suppressant if symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Lansoprazole?
MediHelp rates the interaction as moderate. Apalutamide and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP2C19 and CYP3A4, the main routes of lansoprazole clearance, which may lower lansoprazole exposure. Acid suppression may be weaker.
How serious is the interaction between Apalutamide and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of acid control and increase the lansoprazole dose if needed. Consider an alternative acid suppressant if symptoms persist.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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