Drug interactions
Apalutamide + Levonorgestrel intrauterine
Severity: Minor
Apalutamide and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levonorgestrel from an intrauterine system acts mainly locally with low systemic exposure, so the effect of enzyme induction on contraceptive efficacy is expected to be small. No clear clinically important interaction is established.
What this interaction means in plain words
Apalutamide and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Apalutamide could increase systemic levonorgestrel clearance via CYP3A4, but the local uterine action is largely preserved.
What to do
The device can generally be kept in place; counsel the patient about pregnancy risk if she is of childbearing potential and monitor for unexpected bleeding changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Apalutamide and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levonorgestrel from an intrauterine system acts mainly locally with low systemic exposure, so the effect of enzyme induction on contraceptive efficacy is expected to be small. No clear clinically important interaction is established.
How serious is the interaction between Apalutamide and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The device can generally be kept in place; counsel the patient about pregnancy risk if she is of childbearing potential and monitor for unexpected bleeding changes.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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