Drug interactions
Apalutamide + Methylergonovine
Severity: Minor
Apalutamide and Methylergonovine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce methylergonovine levels, which could lessen its uterotonic effect in postpartum hemorrhage. This is of limited relevance since apalutamide is not used in obstetric patients.
What this interaction means in plain words
Apalutamide and Methylergonovine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction by apalutamide increases methylergonovine metabolism.
What to do
Typically no action is needed; if both are used, monitor for an inadequate uterine response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Methylergonovine?
MediHelp rates the interaction as minor. Apalutamide and Methylergonovine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide may reduce methylergonovine levels, which could lessen its uterotonic effect in postpartum hemorrhage. This is of limited relevance since apalutamide is not used in obstetric patients.
How serious is the interaction between Apalutamide and Methylergonovine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Typically no action is needed; if both are used, monitor for an inadequate uterine response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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