Drug interactions
Apalutamide + Olmesartan
Severity: Minor
Apalutamide and Olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a enzyme and transporter inducer and may lower olmesartan exposure through OATP1B1 induction. The effect on blood pressure control is likely small but could reduce efficacy.
What this interaction means in plain words
Apalutamide and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Olmesartan belongs to Cardiovascular.
Why it happens
Apalutamide weakly induces OATP1B1 and possibly other transporters, which may reduce systemic exposure of olmesartan.
What to do
Monitor blood pressure when starting or stopping apalutamide and increase the olmesartan dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Olmesartan?
MediHelp rates the interaction as minor. Apalutamide and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is a enzyme and transporter inducer and may lower olmesartan exposure through OATP1B1 induction. The effect on blood pressure control is likely small but could reduce efficacy.
How serious is the interaction between Apalutamide and Olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping apalutamide and increase the olmesartan dose if control is inadequate.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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