Drug interactions
Apalutamide + Pitavastatin
Severity: Moderate
Apalutamide and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may induce hepatic uptake and efflux transporters and lower pitavastatin exposure, potentially reducing lipid lowering.
What this interaction means in plain words
Apalutamide and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Pitavastatin belongs to Cardiovascular.
Why it happens
Weak induction of OATP1B1 and BCRP by apalutamide, lowering pitavastatin exposure.
What to do
Monitor lipid levels and raise the pitavastatin dose if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Pitavastatin?
MediHelp rates the interaction as moderate. Apalutamide and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may induce hepatic uptake and efflux transporters and lower pitavastatin exposure, potentially reducing lipid lowering.
How serious is the interaction between Apalutamide and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid levels and raise the pitavastatin dose if the response is inadequate.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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