Drug interactions
Apalutamide + Progesterone intravaginal
Severity: Moderate
Apalutamide and Progesterone intravaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong enzyme induction by apalutamide could lower progesterone exposure. With vaginal use, systemic exposure is the main route for endometrial effects, so luteal support or endometrial protection could be less effective. Clinical data are limited and the effect is predicted from mechanism.
What this interaction means in plain words
Apalutamide and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4 and other enzymes, increasing progesterone metabolism.
What to do
Review whether the combination is clinically relevant, as apalutamide is used in men and rarely alongside progesterone. If both are needed, monitor for loss of progestogenic effect and adjust the progesterone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Progesterone intravaginal?
MediHelp rates the interaction as moderate. Apalutamide and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong enzyme induction by apalutamide could lower progesterone exposure. With vaginal use, systemic exposure is the main route for endometrial effects, so luteal support or endometrial protection could be less effective. Clinical data are limited and the effect is predicted from mechanism.
How serious is the interaction between Apalutamide and Progesterone intravaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether the combination is clinically relevant, as apalutamide is used in men and rarely alongside progesterone. If both are needed, monitor for loss of progestogenic effect and adjust the progesterone dose.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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