Drug interactions
Apalutamide + Progesterone natural
Severity: Moderate
Apalutamide and Progesterone natural: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce circulating progesterone through enzyme induction. This could diminish the therapeutic effect of progesterone. The prediction rests on mechanism rather than dedicated clinical studies.
What this interaction means in plain words
Apalutamide and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4, accelerating progesterone metabolism.
What to do
Monitor for loss of progestogenic effect and adjust the progesterone dose or choose an alternative if the effect is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Progesterone natural?
MediHelp rates the interaction as moderate. Apalutamide and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce circulating progesterone through enzyme induction. This could diminish the therapeutic effect of progesterone. The prediction rests on mechanism rather than dedicated clinical studies.
How serious is the interaction between Apalutamide and Progesterone natural?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of progestogenic effect and adjust the progesterone dose or choose an alternative if the effect is inadequate.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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