Drug interactions
Apalutamide + Rabeprazole
Severity: Minor
Apalutamide and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP3A4 and CYP2C19, which contribute to the metabolism of rabeprazole, although rabeprazole is cleared largely by non-enzymatic routes. Rabeprazole exposure may fall modestly, with a possible loss of acid suppression.
What this interaction means in plain words
Apalutamide and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Apalutamide induction of CYP2C19 and CYP3A4 increases the metabolic clearance of rabeprazole.
What to do
No empirical dose change is needed; watch for reflux or ulcer symptoms and increase the rabeprazole dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Rabeprazole?
MediHelp rates the interaction as minor. Apalutamide and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide induces CYP3A4 and CYP2C19, which contribute to the metabolism of rabeprazole, although rabeprazole is cleared largely by non-enzymatic routes. Rabeprazole exposure may fall modestly, with a possible loss of acid suppression.
How serious is the interaction between Apalutamide and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; watch for reflux or ulcer symptoms and increase the rabeprazole dose if control is inadequate.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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