Drug interactions
Apalutamide + Romidepsin
Severity: Moderate
Apalutamide and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce romidepsin exposure and reduce its antitumor effect in T-cell lymphoma.
What this interaction means in plain words
Apalutamide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4, increasing the metabolism of romidepsin.
What to do
Avoid if a suitable alternative exists; otherwise monitor for lack of response to romidepsin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Romidepsin?
MediHelp rates the interaction as moderate. Apalutamide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce romidepsin exposure and reduce its antitumor effect in T-cell lymphoma.
How serious is the interaction between Apalutamide and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if a suitable alternative exists; otherwise monitor for lack of response to romidepsin.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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