Drug interactions
Apalutamide + Sofosbuvir / velpatasvir
Severity: Contraindicated
Apalutamide and Sofosbuvir / velpatasvir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may substantially lower sofosbuvir and velpatasvir concentrations, risking failure to achieve sustained virologic response. Labeling advises against use with strong inducers.
What this interaction means in plain words
Apalutamide and Sofosbuvir / velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Apalutamide induces P-gp and CYP3A4 (and other CYPs), reducing absorption and increasing clearance of the antivirals.
What to do
Do not coadminister; select an alternative anti-androgen or defer HCV treatment where appropriate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as contraindicated. Apalutamide and Sofosbuvir / velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide may substantially lower sofosbuvir and velpatasvir concentrations, risking failure to achieve sustained virologic response. Labeling advises against use with strong inducers.
How serious is the interaction between Apalutamide and Sofosbuvir / velpatasvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select an alternative anti-androgen or defer HCV treatment where appropriate.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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