Drug interactions
Apalutamide + Sulfadiazine
Severity: Minor
Apalutamide and Sulfadiazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfadiazine is partly cleared via CYP2C9 and N-acetylation, and apalutamide is a weak CYP2C9 inducer. Any reduction in sulfadiazine exposure is likely small.
What this interaction means in plain words
Apalutamide and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Apalutamide weakly induces CYP2C9, which may increase sulfadiazine metabolism.
What to do
No dose adjustment is needed. Monitor clinical response to the anti-infective therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Sulfadiazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Sulfadiazine?
MediHelp rates the interaction as minor. Apalutamide and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfadiazine is partly cleared via CYP2C9 and N-acetylation, and apalutamide is a weak CYP2C9 inducer. Any reduction in sulfadiazine exposure is likely small.
How serious is the interaction between Apalutamide and Sulfadiazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor clinical response to the anti-infective therapy.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
