Drug interactions
Apalutamide + Telmisartan
Severity: Minor
Apalutamide and Telmisartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an inducer of UGT enzymes, and telmisartan is cleared mainly by glucuronidation. Telmisartan exposure may therefore fall, potentially reducing blood pressure control.
What this interaction means in plain words
Apalutamide and Telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Telmisartan belongs to Cardiovascular.
Why it happens
Induction of UGT-mediated glucuronidation by apalutamide increases telmisartan clearance.
What to do
Monitor blood pressure after starting or stopping apalutamide and increase the telmisartan dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Telmisartan?
MediHelp rates the interaction as minor. Apalutamide and Telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is an inducer of UGT enzymes, and telmisartan is cleared mainly by glucuronidation. Telmisartan exposure may therefore fall, potentially reducing blood pressure control.
How serious is the interaction between Apalutamide and Telmisartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping apalutamide and increase the telmisartan dose if control is lost.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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