Drug interactions
Apalutamide + Teniposide
Severity: Major
Apalutamide and Teniposide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of CYP3A4 and may lower teniposide exposure, which is partly cleared through this pathway. Reduced drug levels could weaken the antineoplastic effect of teniposide.
What this interaction means in plain words
Apalutamide and Teniposide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Apalutamide induces CYP3A4 (and related enzymes), increasing the metabolic clearance of teniposide.
What to do
Consider an alternative to apalutamide or teniposide where feasible. If both are needed, monitor closely for reduced antitumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Teniposide?
MediHelp rates the interaction as major. Apalutamide and Teniposide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong inducer of CYP3A4 and may lower teniposide exposure, which is partly cleared through this pathway. Reduced drug levels could weaken the antineoplastic effect of teniposide.
How serious is the interaction between Apalutamide and Teniposide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to apalutamide or teniposide where feasible. If both are needed, monitor closely for reduced antitumor response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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