Drug interactions
Apalutamide + Tenofovir af
Severity: Moderate
Apalutamide and Tenofovir af: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir alafenamide is a P-gp and BCRP substrate, and apalutamide induces P-gp and CYP3A4. Lower tenofovir exposure could reduce antiviral efficacy, particularly in HIV or hepatitis B treatment.
What this interaction means in plain words
Apalutamide and Tenofovir af can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces P-gp and other transporters, decreasing tenofovir alafenamide absorption.
What to do
Co-administration is generally not recommended with strong P-gp inducers, so consider tenofovir disoproxil or other options. If used together, monitor viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Tenofovir af?
MediHelp rates the interaction as moderate. Apalutamide and Tenofovir af can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir alafenamide is a P-gp and BCRP substrate, and apalutamide induces P-gp and CYP3A4. Lower tenofovir exposure could reduce antiviral efficacy, particularly in HIV or hepatitis B treatment.
How serious is the interaction between Apalutamide and Tenofovir af?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-administration is generally not recommended with strong P-gp inducers, so consider tenofovir disoproxil or other options. If used together, monitor viral load.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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