Drug interactions
Apalutamide + Tenofovir df
Severity: Minor
Apalutamide and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil is a P-gp substrate, and apalutamide may weakly induce efflux transporters. Any reduction in tenofovir exposure is likely small and unlikely to change efficacy.
What this interaction means in plain words
Apalutamide and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Apalutamide may weakly induce P-gp and BCRP, which could slightly reduce tenofovir absorption.
What to do
No dose adjustment is needed. Monitor viral load as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Tenofovir df?
MediHelp rates the interaction as minor. Apalutamide and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenofovir disoproxil is a P-gp substrate, and apalutamide may weakly induce efflux transporters. Any reduction in tenofovir exposure is likely small and unlikely to change efficacy.
How serious is the interaction between Apalutamide and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor viral load as part of routine care.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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