Drug interactions
Apalutamide + Tenofovir disoproxil
Severity: Minor
Apalutamide and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an inducer of several drug-handling proteins and may modestly lower exposure to some co-administered drugs. A reduction in tenofovir levels is theoretically possible but is not well characterized. The clinical significance for antiviral efficacy is uncertain.
What this interaction means in plain words
Apalutamide and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak induction of efflux transporters such as BCRP by apalutamide, which may lower tenofovir exposure; this is not firmly established.
What to do
No empirical dose change is needed. Monitor HIV RNA or HBV DNA at routine intervals to confirm continued virologic suppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Apalutamide and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is an inducer of several drug-handling proteins and may modestly lower exposure to some co-administered drugs. A reduction in tenofovir levels is theoretically possible but is not well characterized. The clinical significance for antiviral efficacy is uncertain.
How serious is the interaction between Apalutamide and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor HIV RNA or HBV DNA at routine intervals to confirm continued virologic suppression.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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