Drug interactions
Apalutamide + Tezacaftor
Severity: Major
Apalutamide and Tezacaftor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide, a strong CYP3A4 inducer, can markedly reduce tezacaftor concentrations because tezacaftor is mainly cleared by CYP3A4. This may lead to loss of CFTR modulator efficacy.
What this interaction means in plain words
Apalutamide and Tezacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 by apalutamide accelerates tezacaftor metabolism.
What to do
Avoid concomitant use, as labeling for tezacaftor/ivacaftor advises against strong CYP3A inducers. Use an alternative antiandrogen if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Tezacaftor?
MediHelp rates the interaction as major. Apalutamide and Tezacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide, a strong CYP3A4 inducer, can markedly reduce tezacaftor concentrations because tezacaftor is mainly cleared by CYP3A4. This may lead to loss of CFTR modulator efficacy.
How serious is the interaction between Apalutamide and Tezacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use, as labeling for tezacaftor/ivacaftor advises against strong CYP3A inducers. Use an alternative antiandrogen if possible.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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