Drug interactions
Apalutamide + Triazolam
Severity: Moderate
Apalutamide and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide can substantially reduce triazolam levels because triazolam undergoes extensive CYP3A4 metabolism. Hypnotic efficacy may be lost, and rebound insomnia may occur.
What this interaction means in plain words
Apalutamide and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4, accelerating first-pass and systemic triazolam metabolism.
What to do
Monitor hypnotic response and consider an alternative agent not dependent on CYP3A4, such as temazepam. Avoid escalating triazolam doses without reassessment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Triazolam?
MediHelp rates the interaction as moderate. Apalutamide and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide can substantially reduce triazolam levels because triazolam undergoes extensive CYP3A4 metabolism. Hypnotic efficacy may be lost, and rebound insomnia may occur.
How serious is the interaction between Apalutamide and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hypnotic response and consider an alternative agent not dependent on CYP3A4, such as temazepam. Avoid escalating triazolam doses without reassessment.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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