Drug interactions
Apalutamide + Venlafaxine
Severity: Moderate
Apalutamide and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of CYP3A4 and also induces other enzymes, which can lower exposure to drugs cleared by these pathways. Venlafaxine is mainly metabolised by CYP2D6 with a minor CYP3A4 contribution, so the effect is probably modest, but loss of antidepressant effect is possible.
What this interaction means in plain words
Apalutamide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Venlafaxine belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4 (and other metabolic enzymes), potentially increasing venlafaxine clearance via its minor pathway.
What to do
Monitor for reduced antidepressant response and discontinuation-like symptoms when apalutamide is started. Increase the venlafaxine dose based on clinical response if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Venlafaxine?
MediHelp rates the interaction as moderate. Apalutamide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong inducer of CYP3A4 and also induces other enzymes, which can lower exposure to drugs cleared by these pathways. Venlafaxine is mainly metabolised by CYP2D6 with a minor CYP3A4 contribution, so the effect is probably modest, but loss of antidepressant effect is possible.
How serious is the interaction between Apalutamide and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and discontinuation-like symptoms when apalutamide is started. Increase the venlafaxine dose based on clinical response if needed.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
