Drug interactions
Apixaban + Cilostazol
Severity: Moderate
Apixaban and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol inhibits platelet aggregation and, with apixaban, can increase the likelihood of bleeding. The risk is greatest in older patients or those with other bleeding risk factors.
What this interaction means in plain words
Apixaban and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Cilostazol belongs to Cardiovascular.
Why it happens
Additive antiplatelet (PDE3 inhibition) and anticoagulant (factor Xa inhibition) effects.
What to do
Monitor for bleeding and hemoglobin, and reassess the need for cilostazol. Avoid in patients with active bleeding or high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Apixaban with Cilostazol?
MediHelp rates the interaction as moderate. Apixaban and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cilostazol inhibits platelet aggregation and, with apixaban, can increase the likelihood of bleeding. The risk is greatest in older patients or those with other bleeding risk factors.
How serious is the interaction between Apixaban and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin, and reassess the need for cilostazol. Avoid in patients with active bleeding or high bleeding risk.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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