Drug interactions
Apixaban + Etodolac
Severity: Major
Apixaban and Etodolac: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac impairs platelet function and can injure the gastrointestinal mucosa, adding to the bleeding risk from apixaban. Clinically significant gastrointestinal or other bleeding may result.
What this interaction means in plain words
Apixaban and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: NSAID antiplatelet effect and mucosal injury combined with factor Xa inhibition.
What to do
Prefer paracetamol or another non-NSAID analgesic. If etodolac is necessary, use the lowest dose for the shortest time, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Etodolac?
MediHelp rates the interaction as major. Apixaban and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac impairs platelet function and can injure the gastrointestinal mucosa, adding to the bleeding risk from apixaban. Clinically significant gastrointestinal or other bleeding may result.
How serious is the interaction between Apixaban and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or another non-NSAID analgesic. If etodolac is necessary, use the lowest dose for the shortest time, consider gastroprotection and monitor for bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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