Drug interactions
Apixaban + Imatinib
Severity: Moderate
Apixaban and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and bleeding, which adds to the hemorrhagic risk of apixaban. Imatinib may also modestly increase apixaban exposure through CYP3A4 inhibition.
What this interaction means in plain words
Apixaban and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Additive bleeding risk from imatinib thrombocytopenia plus anticoagulation, with possible weak CYP3A4 inhibition raising apixaban levels.
What to do
Monitor platelet counts and signs of bleeding during combined use. Hold or reduce anticoagulation if marked thrombocytopenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Apixaban with Imatinib?
MediHelp rates the interaction as moderate. Apixaban and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and bleeding, which adds to the hemorrhagic risk of apixaban. Imatinib may also modestly increase apixaban exposure through CYP3A4 inhibition.
How serious is the interaction between Apixaban and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and signs of bleeding during combined use. Hold or reduce anticoagulation if marked thrombocytopenia develops.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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