Drug interactions
Apixaban + Lenacapavir
Severity: Moderate
Apixaban and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and also inhibits P-gp, so it may raise apixaban exposure and bleeding risk. The inhibition may persist for months after the last subcutaneous dose because of its long half-life.
What this interaction means in plain words
Apixaban and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces apixaban clearance.
What to do
Monitor closely for bleeding signs, including after starting apixaban in patients who recently received lenacapavir. Consider an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Apixaban with Lenacapavir?
MediHelp rates the interaction as moderate. Apixaban and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and also inhibits P-gp, so it may raise apixaban exposure and bleeding risk. The inhibition may persist for months after the last subcutaneous dose because of its long half-life.
How serious is the interaction between Apixaban and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding signs, including after starting apixaban in patients who recently received lenacapavir. Consider an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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