Drug interactions
Apixaban + Quinidine
Severity: Moderate
Apixaban and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits CYP3A4 and P-glycoprotein and may increase apixaban exposure. This raises bleeding risk, though quinidine is a weaker inhibitor than strong dual inhibitors.
What this interaction means in plain words
Apixaban and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of P-glycoprotein and CYP3A4 by quinidine reduces apixaban clearance.
What to do
Monitor for bleeding signs and renal function, particularly with other risk factors. Consider apixaban dose review in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Quinidine?
MediHelp rates the interaction as moderate. Apixaban and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits CYP3A4 and P-glycoprotein and may increase apixaban exposure. This raises bleeding risk, though quinidine is a weaker inhibitor than strong dual inhibitors.
How serious is the interaction between Apixaban and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and renal function, particularly with other risk factors. Consider apixaban dose review in high-risk patients.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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