Drug interactions
Apixaban + Sertraline
Severity: Moderate
Apixaban and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline impairs platelet function by depleting platelet serotonin, which adds to the anticoagulant effect of apixaban. The combination raises the risk of bleeding, particularly gastrointestinal bleeding.
What this interaction means in plain words
Apixaban and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: SSRI-induced platelet dysfunction combined with factor Xa inhibition.
What to do
Monitor for signs of bleeding and check hemoglobin if symptoms arise. Consider gastroprotection in patients at high risk of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Apixaban with Sertraline?
MediHelp rates the interaction as moderate. Apixaban and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline impairs platelet function by depleting platelet serotonin, which adds to the anticoagulant effect of apixaban. The combination raises the risk of bleeding, particularly gastrointestinal bleeding.
How serious is the interaction between Apixaban and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check hemoglobin if symptoms arise. Consider gastroprotection in patients at high risk of GI bleeding.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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