Drug interactions
Apomorphine + Butorphanol
Severity: Moderate
Apomorphine and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause drowsiness, sudden sleep onset and hypotension, and butorphanol adds sedation and dizziness. The combination can impair alertness and increase fall risk.
What this interaction means in plain words
Apomorphine and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Butorphanol belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Monitor sedation and orthostatic blood pressure, and reduce the butorphanol dose if drowsiness develops. Counsel patients on fall risk and avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Butorphanol?
MediHelp rates the interaction as moderate. Apomorphine and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause drowsiness, sudden sleep onset and hypotension, and butorphanol adds sedation and dizziness. The combination can impair alertness and increase fall risk.
How serious is the interaction between Apomorphine and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, and reduce the butorphanol dose if drowsiness develops. Counsel patients on fall risk and avoid driving.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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