Drug interactions
Apomorphine + Cisapride
Severity: Contraindicated
Apomorphine and Cisapride: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Used together they may raise the risk of torsades de pointes and sudden cardiac death, especially in patients with other risk factors.
What this interaction means in plain words
Apomorphine and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Cisapride belongs to Gastrointestinal Tract.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Do not coadminister; use an alternative for gastric motility or nausea. If apomorphine is essential, stop cisapride.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cisapride
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
- Cisapride + Clarithromycin Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
- Apomorphine + Palonosetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Cisapride?
MediHelp rates the interaction as contraindicated. Apomorphine and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval. Used together they may raise the risk of torsades de pointes and sudden cardiac death, especially in patients with other risk factors.
How serious is the interaction between Apomorphine and Cisapride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative for gastric motility or nausea. If apomorphine is essential, stop cisapride.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Artemether, Azithromycin, Ceritinib. The full list is on the Cisapride page.
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