Drug interactions
Apomorphine + Clemastine
Severity: Moderate
Apomorphine and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause somnolence and sudden sleep onset, and a sedating antihistamine may add to drowsiness. This may impair alertness and safe driving.
What this interaction means in plain words
Apomorphine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Clemastine belongs to Respiratory.
Why it happens
Additive CNS depression from dopamine agonism and H1-receptor blockade.
What to do
Monitor for excessive daytime sleepiness and advise against driving if affected. Use a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Clemastine?
MediHelp rates the interaction as moderate. Apomorphine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause somnolence and sudden sleep onset, and a sedating antihistamine may add to drowsiness. This may impair alertness and safe driving.
How serious is the interaction between Apomorphine and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive daytime sleepiness and advise against driving if affected. Use a non-sedating antihistamine where possible.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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