Drug interactions
Apomorphine + Donepezil
Severity: Moderate
Apomorphine and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, and donepezil can also cause bradycardia. Apomorphine can cause orthostatic hypotension and nausea, and combined use may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Apomorphine and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Donepezil belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation, with possible additive bradycardia and hypotension.
What to do
Obtain a baseline ECG in patients with cardiac disease or other QT risk factors and correct potassium and magnesium. Monitor for syncope, palpitations and orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Donepezil?
MediHelp rates the interaction as moderate. Apomorphine and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, and donepezil can also cause bradycardia. Apomorphine can cause orthostatic hypotension and nausea, and combined use may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Apomorphine and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac disease or other QT risk factors and correct potassium and magnesium. Monitor for syncope, palpitations and orthostatic hypotension.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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