Drug interactions
Apomorphine + Indapamide
Severity: Major
Apomorphine and Indapamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can prolong the QT interval, and indapamide can cause hypokalemia and hypomagnesemia that increase the risk of torsades de pointes. The combination should be handled carefully in patients with other risk factors.
What this interaction means in plain words
Apomorphine and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apomorphine belongs to Central Nervous System; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with diuretic-induced electrolyte depletion increasing arrhythmia susceptibility.
What to do
Check and correct potassium and magnesium before and during therapy, and obtain a baseline ECG. Consider an alternative to the diuretic in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Indapamide?
MediHelp rates the interaction as major. Apomorphine and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apomorphine can prolong the QT interval, and indapamide can cause hypokalemia and hypomagnesemia that increase the risk of torsades de pointes. The combination should be handled carefully in patients with other risk factors.
How serious is the interaction between Apomorphine and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during therapy, and obtain a baseline ECG. Consider an alternative to the diuretic in patients with other QT risk factors.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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