Drug interactions
Apomorphine + Ketamine
Severity: Moderate
Apomorphine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and apomorphine can cause orthostatic hypotension. Together they may increase drowsiness and blood pressure instability.
What this interaction means in plain words
Apomorphine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hemodynamic effects.
What to do
Monitor sedation and blood pressure, including on standing when appropriate, and titrate ketamine cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Ketamine?
MediHelp rates the interaction as moderate. Apomorphine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and apomorphine can cause orthostatic hypotension. Together they may increase drowsiness and blood pressure instability.
How serious is the interaction between Apomorphine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, including on standing when appropriate, and titrate ketamine cautiously.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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