Drug interactions
Apomorphine + Octreotide
Severity: Moderate
Apomorphine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine has been associated with QT prolongation, and octreotide can cause bradycardia and conduction changes. Combined use may increase proarrhythmic risk, especially in patients with cardiac disease.
What this interaction means in plain words
Apomorphine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Check a baseline ECG and monitor QTc and heart rate, correcting electrolyte abnormalities. Avoid use in patients with congenital long QT or other significant QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Octreotide?
MediHelp rates the interaction as moderate. Apomorphine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine has been associated with QT prolongation, and octreotide can cause bradycardia and conduction changes. Combined use may increase proarrhythmic risk, especially in patients with cardiac disease.
How serious is the interaction between Apomorphine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc and heart rate, correcting electrolyte abnormalities. Avoid use in patients with congenital long QT or other significant QT risk factors.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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